B cells in multiple sclerosis

B cells in multiple sclerosis

Blog Article

B lymphocytes have essential roles in the autoimmune pathogenesis of multiple sclerosis (MS).They regulate the autoimmune Clothing - Mens Bottoms - Pants response and participate in the development of the CNS lesions.This review discusses nature and functions of B cells in MS, and retraces the recruitment of brain-autoimmune B cells from the B cell repertoire.Multiple sclerosis is commonly considered as an autoimmune demyelinating disease, where myelin-reactive T cells enter the CNS from outside, and drive the inflammatory changes that ultimately create the degenerative MS plaque.

Most therapeutic strategies focus on eliminating Travel or mitigating these pathogenic T cells.Less consideration has been devoted to the role of autoimmune B cells in the autoimmune pathogenesis.Indeed, this role is now supported by a number of convergent lines of evidence, which are briefly outlined in a first part of this overview.A second part describes experimental studies in transgenic mouse models of brain autoimmunity, EAE, which relate to possible functions of autoimmune B cells and to their recruitment from the regular B cell repertoire.